职称:教授
研究方向:植物病害防治
研究群:草地有害生物及微生物
研究群:Pests and microorganisms
Tel: Fax: Email:yqliu@lzu.edu.cn基本情况
刘映前, 男, 汉族, 生于1979年6月, 中共党员, 三级教授, 博士生导师,天然药物化学生物学研究所所长。甘肃省飞天学者, 甘肃省陇原青年创新创业团队负责人, 甘肃省中藏药功效物质开发与利用行业技术中心主任。近年来先后在J. Agric. Food Chem. J. Med. Chem、Europ. J. Med. Chem等高水平SCI论文发表70余篇,申请国家发明专利80余项,PCT专利1项,成果转化5项,作为副主编参编专著3部。先后承担国家重点研发计划、国家自然科学基金、甘肃省重点研发计划、甘肃省科技创新专项以及浙江省重点建设高校优势特色学科中药学重点项目等科技项目20余项,服务企业合作横向项目以及与企业联合的产学研课题40余项。
教育经历
2002.9-2007.6 兰州大学 功能有机分子化学国家重点实验室,博士(硕博连读)
工作经历
2009.3-2013.3 兰州大学生命科学学院,博士后
2011.7-2012.7 美国北卡罗莱纳大学教堂山分校药学院,访问学者
2016.12-2020.12 兰州大学药学院,院长
2014.5-至今 兰州大学药学院,教授/博导
2010.5-2014.5 兰州大学药学院, 副教授/硕导
2007.7-2010.5 兰州大学药学院, 讲师
学术任职
中国民族医药协会民族医药教育专业委员会副会长,甘肃省药学会副理事长,中国生物医药整合联盟理事,甘肃省化学会理事、甘肃省化学会药物化学主任委员和甘肃省药学会天然药物与医药产业经济主任委员、中国民族医药协会芳香医药分会副主任委员等职务。
荣誉与奖励
先后获甘肃药学会药学发展一、二等奖、中华中医药学会科学技术奖(政策研究奖)、南京市科技进步三等奖。
课程教学
本科生培养
研究生培养
博士后合作者
当前研究领域
植物病害防治
研究项目
1. 主持国家自然科学基金面上项目(21877056): 源于天然源奎宁类生物碱的全新杀菌化学实体的设计合成与结构优化研究,2019-01至2022-12。
2.主持甘肃省重点研发计划国际科技合作专项(18YF1WA115): 巴基斯坦四种特色药用植物生物碱类活性成分的合作研究, 2018-01至2020-12。
3.参加科技部国家重点研发计划(2017YFD0201400):天然绿色生物农药的合成
生物学与组合合成技术,2017-01至2020-12, 承担该项目的子课题4的“活性代谢物结构修饰和多样性衍生优化”任务。
4. 主持国家自然科学基金面上项目(21672092): 新型自旋标记喹啉类拓扑异构酶抑制剂的设计合成及其生物活性研究,2017-01至2020-12。
5.主持国家自然科学基金面上项目(31371975):基于结构多样性策略进行喜树
碱类生物碱的结构优化及其杀虫活性研究,2014-01至2017-12。
6.主持国家自然科学基金青年项目(30800720):喜树碱衍生物的合成、杀虫构
效关系及致不育机理研究,2009-01至2011-12。
7. 主持横向项目:《甘肃省中药炮制规范》(2009 年版)中药典品种特殊炮制规格标准制修订,2019-06至2020-01。
8. 主持横向项目:新型生物活性先导结构的发现与活性评价研究(I、II),2017-04至2023-04。
9. 主持横向项目: 新型兽用抑菌活性先导发现, 2020-09至2026-09。
10. 主持横向项目: 多肽抗菌药物筛选,2019-06至2020-12。
其他成果
[1] Yong-Jia Chen, Hua Liu, Shao-Yong Zhang, Hu Li, Kun-Yuan Ma, Ying-Qian Liu,* Xiao-Dan Yin,Rui Zhou, Yin-Fang Yan, Ren-Xuan Wang, Ying-Hui He, Qing-Ru Chu, and Chen Tang. Design, Synthesis, and Antifungal Evaluation of Cryptolepine Derivatives against Phytopathogenic Fungi. J. Agric. Food Chem. 2021, 69, 1259~1271 (SCI一区,影响因子:4.192).
[2] Junmin Zhang, Susan L. Morris-Natschke, Di Ma, Xiao-Fei Shang, Chen-Jie Yang, Ying-Qian Liu*, Kuo-Hsiung Lee*. Biologically active indolizidine alkaloids. Med. Res. Rev. 2021, 41, 928~960 (SCI一区,影响因子:9.3).
[3] Xiao-Fei Shang, Li-Xia Dai, Chen-Jie Yang, Xiao Guo, Ying-Qian Liu*, Xiao-Lou Miao, Ji-Yu Zhang*.A value-added application of eugenol as acaricidal agent: The mechanism of action and the safety evaluation. Journal of Advanced Research, 2021, https://doi.org/10.1016/j.jare.2020.12.010 (SCI二区,影响因子:6.992).
[4] Jia-Kai Zhu, Jian-Mei Gao, Cheng-Jie Yang, Xiao-Fei Shang, Zhong-Min Zhao, Raymond Kobla Lawoe, Rui Zhou, Yu Sun, Xiao-Dan Yin, Ying-Qian Liu*. Design, synthesis, and antifungal evaluation of neocryptolepine derivatives against phytopathogenic fungi. J. Agric. Food Chem. 2020, 68, 8, 2306-2315 (SCI一区,影响因子:4.192).
[5]Xiao-Dan Yin, Kun-Yuan Ma,Yu-Ling Wang,Yu Sun,Xiao-Fei Shang,Zhong-Min Zhao,Ren-Xuan Wang,Yong-Jia Chen,Jia-Kai Zhu, Ying-Qian Liu*. Design, Synthesis, and Antifungal Evaluation of 8-Hydroxyquinoline Metal Complexes against Phytopathogenic Fungi.
J. Agric. Food Chem. 2020, 68, 40, 11096-11104 (SCI一区,影响因子:4.192).
[6] Xiao-Fei Shang, Cheng-Jie Yang,Susan L. Morris-Natschke, Jun-Cai Li, Xiao-Dan Yin, Ying-Qian Liu*, Xiao Guo, Jing-Wen Peng, Masuo Goto, Ji-Yu Zhang, Ku-Hsiung Lee *. Biologically active isoquinoline alkaloids covering 2014–2018. Med. Res. Rev. 2020, 40, 2212~2289 (SCI一区,影响因子:9.3).
[7] Yin-Fang Yan, Cheng-Jie Yang, Xiao-Fei Shang, Zhong-Min Zhao, Ying-qian Liu*, Rui Zhou, Hua Liu, Tian-Lin Wu, Wen-Bin Zhao, Yu-Ling Wang, Guan-Fang Hu, Fang Qin, Ying-Hui He, Hai-Xin Li, Sha-Sha Du. Bioassay-guided isolation of two antifungal compounds from Magnolia
officinalis, and the mechanism of action of honokiol. Pestic. Biochem. Physiol., 2020, 17, 104705 (SCI二区,影响因子:2.751).
[8] Guan-Zhou Yang, Jian Zhang, Jing-Wen Peng, Zhi-Jun Zhang, Wen-Bin Zhao, Ren-Xuan Wang, Kun-Yuan Ma, Jun-Cai Li, Ying-Qian Liu *, Zhong-Min Zhao, Xiao-Fei Shang. Discovery of luotonin A analogues as potent fungicides and insecticides: Design, synthesis and biological evaluation inspired by natural alkaloid. Europ. J. Med. Chem. 2020, 194, 112253 (SCI一区,影响因子:5.572).
[9] Jun-cai Li, Ren-xuan Wang, Yu Sun, Jia-kai Zhu, Guan-fang Hu, Yu-ling Wang, Rui Zhou, Zhong-min Zhao, Ying-qian Liu*, Jing-wen Peng, Yin-fang Yan, Xiao-fei Shang. Design, synthesis and antifungal activity evaluation of isocryptolepine derivatives. Bioorg. Chem. 2019, 92, 103266 (SCI二区,影响因子:4.831).
[10] Guan-Zhou Yang, Jia-Kai Zhu, Xiao-Dan Yin, Yin-Fang Yan, Yu-Ling Wang, Xiao-Fei Shang, Ying-Qian Liu*, Zhong-Min Zhao, Jing-Wen Peng, Hua Liu. Design, synthesis, and antifungal evaluation of novel quinoline derivatives inspired from natural quinine alkaloids. J. Agric. Food Chem. 2019, 67, 11340-11353 (SCI一区,影响因子:4.192).
[11] Zhong-min Zhao, Xiao-fei Shang, Raymond Kobla Lawoe, Ying-qian Liu*, Rui Zhou, Yu Sun, Yin-fang Yan, Jun-cai Li, Guan-zhou Yang, Cheng-jie Yang. Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine. Pestic. Biochem. Physiol., 2019, 159, 51-58 (SCI二区,影响因子:2.751).
[12] Xiao-Fei Shang, Zhong-Min Zhao, Jun-Cai Li, Guan-Zhou Yang, Ying-Qian Liu*, Li-Xia Dai, Zhi-Jun Zhang, Zhi-Gang Yang, Xiao-Lou Miao, Cheng-Jie Yang, Ji-Yu Zhang. Insecticidal and antifungal activities of Rheum palmatum L. anthraquinones and structurally related compounds. Ind. Crop. Prod. 2019, 137, 508~520 (SCI一区,影响因子:4.244).
[13] Xiao-Fei Shang, Li-Xia Dai, Ying-Qian Liu*, Zhong-Min Zhao, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Acaricidal activity and enzyme inhibitory activity of active compounds of essential oils against Psoroptes cuniculi. Vet. Parasitol. 2019, 267, 54–59 (SCI二区,影响因子:2.157).
[14] Xiao-Fei Shang, Susan L., Morris-Natschke, Ying-Qian Liu*, Xiao Guo, Xiao-Shan Xu, Masuo Goto, Jun-Cai Li, Guan-Zhou Yang, Kuo-Hsiung Lee*. Biologically active quinoline and quinazoline alkaloids part I. Med. Res.Rev. 2018, 38, 775-828 (SCI一区,影响因子:9.3).
[15] Xiao-Fei Shang, Susan L. Morris-Natschke, Guan-Zhou Yang, Ying-Qian Liu*, Xiao Guo, Xiao-Shan Xu, Masuo Goto, Jun-Cai Li, Ji-Yu Zhang, Kuo-Hsiung Lee*. Biologically active quinoline and quinazoline alkaloids part II. Med. Res. Rev. 2018, 38, 1614-1660 (SCI一区,影响因子:9.3).
[16] Jian Zhang, Xiang Nan, Hai-Tao Yu, Pi-Le Cheng, Yan Zhang, Ying-Qian Liu*, Shao-Yong Zhang, Guan-Fang Hu, Huanxiang Liu*, An-Liang Chen. Synthesis, biological activities and structure-activity relationships for new avermectin analogues. Europ. J. Med. Chem. 2016, 121, 422-432 (SCI一区,影响因子:5.572).
[17] Mei-Juan Wang, Xiang Nan, Gang Feng, Hai-Tao Yu, Guan-Fang Hu, Ying-Qian Liu*. Design, synthesis and bioactivity evaluation of novel acylthiourea derivatives of cantharidin. Ind. Crop. Prod. 2014, 55, 11-18.
[18] Jing Zhang, Li-Ting Yan, En-Lin Yuan, Hai-Xin Ding, Huo-Chun Ye, Zheng-Ke Zhang, Chao Yan, Ying-Qian Liu*, Gang Feng*. Antifungal Activity of Compounds Extracted from Cortex Pseudolaricis against Colletotrichum gloeosporioides. J. Agric. Food Chem. 2014, 62, 4905-4910 (SCI一区,影响因子:4.192).
[19] Mei-Juan Wang, Xiao-Bo Zhao, Dan Wu, Ying-Qian Liu,*, Yan Zhang, Xiang Nan, Huan-xiang Liu, Hai-Tao Yu, Guan-Fang Hu, and Li-Ting Yan. Design, Synthesis, Crystal Structure, Insecticidal Activity, Molecular Docking, and QSAR Studies of Novel N3-Substituted Imidacloprid Derivatives. J. Agric. Food Chem. 2014, 62, 5429-5442 (SCI一区,影响因子:4.192).
[20] Wen-Qun Li, Zhi-Jun Zhang, Xiang Nan, Ying-Qian Liu*, Guan-Fang Hu, Hai-Tao Yu, Xiao-Bo Zhao, Dan Wua, Li-Ting Yan. Design, synthesis and bioactivity evaluation of novel benzophenone hydrazone derivatives. Pest Manag. Sci. 2014, 70, 667-673 (SCI一区,影响因子:3.750).